Whole-Genome Sequencing of Mycobacterium tilburgii Strain MEPHI

"Mycobacterium tilburgii" Infections

occurring in South Korea because high similarities (98.6%–99.8%) are found among 4 subspecies of R. conorii. Multilocus sequence typing can help differentiate among these subspecies (6). This study provided a model to amplify SFG rickettsial DNA from sera of patients, and it will be helpful in surveillance of these diseases. However, the results should be interpreted more carefully in the conte...

Functional Analysis Using Whole-Genome Sequencing of a Drug-Sensitive Mycobacterium tuberculosis Strain from Peru

We report the whole-genome sequence of a Latin American-Mediterranean (LAM) lineage drug-sensitive Mycobacterium tuberculosis strain from Peru, INS-SEN. The functional analysis revealed more mutations in secondary metabolite biosynthesis, transport, and catabolism (clusters of orthologous groups [COG] category Q) than for other LAM-sensitive strains. This study contributes to the understanding ...

Clinical use of whole genome sequencing for Mycobacterium tuberculosis.

Drug-resistant tuberculosis (TB) remains a major challenge to global health and to healthcare in the UK. In 2014, a total of 6,520 cases of TB were recorded in England, of which 1.4 % were multidrug-resistant TB (MDR-TB). Extensively drug-resistant TB (XDR-TB) occurs at a much lower rate, but the impact on the patient and hospital is severe. Current diagnostic methods such as drug susceptibilit...

Whole-genome sequencing of Mycobacterium tuberculosis as an epidemiological marker

Whole-genome sequencing of Mycobacterium tuberculosis as an epidemiological marker